Mapping the kinase domain of Janus Kinase 3

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3105-10. doi: 10.1016/s0960-894x(03)00657-7.

Abstract

The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.

MeSH terms

  • Adjuvants, Immunologic / chemistry*
  • Animals
  • Binding Sites
  • Cell Division / drug effects
  • Drug Design
  • Edema / drug therapy
  • Enzyme Inhibitors / chemistry
  • Indoles / chemistry
  • Inhibitory Concentration 50
  • Interleukin-2 / pharmacology
  • Janus Kinase 3
  • Mice
  • Oxyquinoline / chemistry
  • Phosphorylation / drug effects
  • Protein Binding
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / chemistry*
  • Protein-Tyrosine Kinases / immunology*
  • Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / drug effects
  • Structure-Activity Relationship

Substances

  • Adjuvants, Immunologic
  • Enzyme Inhibitors
  • Indoles
  • Interleukin-2
  • Oxyquinoline
  • Protein-Tyrosine Kinases
  • Jak3 protein, mouse
  • Janus Kinase 3