Abstract
The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.
MeSH terms
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Adjuvants, Immunologic / chemistry*
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Animals
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Binding Sites
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Cell Division / drug effects
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Drug Design
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Edema / drug therapy
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Enzyme Inhibitors / chemistry
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Indoles / chemistry
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Inhibitory Concentration 50
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Interleukin-2 / pharmacology
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Janus Kinase 3
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Mice
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Oxyquinoline / chemistry
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Phosphorylation / drug effects
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Protein Binding
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Protein Structure, Tertiary
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Protein-Tyrosine Kinases / chemistry*
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Protein-Tyrosine Kinases / immunology*
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Protein-Tyrosine Kinases / metabolism
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Signal Transduction / drug effects
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Structure-Activity Relationship
Substances
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Adjuvants, Immunologic
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Enzyme Inhibitors
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Indoles
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Interleukin-2
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Oxyquinoline
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Protein-Tyrosine Kinases
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Jak3 protein, mouse
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Janus Kinase 3